DermaClae vs. AlloClae: What’s the Difference?

AlloClae has been one of the hottest new products over the last year, and now, we are introducing a novel new product called DermaClae. DermaClae is the sister product to AlloClae by Tiger Aesthetics. Both are processed donor fat, both come off the shelf, and neither one requires liposuction or a donor site. AlloClae was the first filler designed specifically for the body; DermaClae has a similar structure but designed specifically for the face. Both AlloClae and DermaClae are regenerative products from donor fat that have been processed to create more than an alternative to traditional HA fillers; they are creating an entire new opportunity built around regenerative aesthetics. They are composed of adipocyte cell membranes and extracellular matrix; each is specifically designed to enhance the properties for the specific uses it was designed for in its use. Alloclae was designed to have significant structural strength that made it ideal for body augmentation such as for the buttock, hips, and breast augmentation. This same structural strength is why it was not ideal for the face. DermaClae will have a different ratio of adipocyte cell membranes and extracellular matrix to give it a softer smoother feel that is specifically designed for the face. They are both unique innovative products that will change the world of aesthetics, pushing the field of regenerative medicine forward.

What AlloClae did for body patients

AlloClae was the first filler actually designed for the body. Not a facial product stretched into a bigger area, and not a line extension of something that already existed. That distinction matters more than most patients or plastic surgeons realize. There was a different vision from the start, and the properties of the product were designed to meet some of these specific needs of the body. The same is true for DermaClae. Rather than just using the same product and putting it in a smaller syringe/canister, it was designed and processed specifically for the face. It was created from processed donor fat, but a unique ratio of adipocyte membranes and extracellular matrix was used to create something unique for the face.

The makeup of AlloClae is 60% adipocyte cell membrane and 40% extracellular matrix. This composition is important as it gives patients an immediate volume with real structural integrity, plus regenerative properties over time.

It holds shape. It projects. It sculpts.

And because it is fat, it looks and feels like your own tissue, which is exactly how we maximize the natural feel and appearance of the augmentation.

AlloClae at our practice (Austin Plastic Surgeon) has most commonly been used initially for hip dips, buttock projection, and liposuction contour deformities, and has quickly expanded to breast augmentation, hand rejuvenation, and labia enhancement. Liposuction contour irregularities have been challenging previously, as many patients have been hesitant to do more liposuction to correct liposuction, or have limited fat available for fat transfer. Fat grafting has been the primary option for hip, buttock, and liposuction contour deformities, but it means another operation and another donor site, which many patients on their weight loss journey don’t have available. AlloClae gave us something to offer in the office, and for some patients, an option when fat was not available.

It will be interesting to see how AlloClae develops over the next couple years. There is a possibility that for liposuction contour deformity, trauma reconstruction, and anywhere with a significant amount of scar tissue, AlloClae may be the first line choice as it may have better survival since it will not need blood vessels or a perfect bed to survive.

This created a choice and opportunity that many of our patients never had prior to AlloClae. So many of our patients felt defeated or disappointed as they just felt as if they didn’t have any options and that is not true anymore. AlloClae has changed the world of opportunities for so many of our patients.

Then patients started asking about their face

The face has always been an area that we have treated in aesthetics with fillers, initially collagen fillers. When we moved from collagen fillers to HA (hyaluronic acid) fillers, we thought “how did we ever live without these?”

Guess what? The next wave is coming soon. So many of our patients have been looking for a regenerative option that fits their natural lifestyle. DermaClae is the option so many of our patients have been waiting for in facial rejuvenation. DermaClae is designed for the face and other delicate areas where a fine, smooth product is needed.

Same processed donor fat, different formulation, built specifically for the face and other delicate areas.

DermaClae carries a higher ratio of extracellular matrix and a much finer texture. This was by design. A product that is structurally strong enough to lift a hip dip is not what you want for your facial rejuvenation. Facial work is artistic, strategic, and about precision. It is smooth, targeted volume in small amounts, and it has to move naturally while still providing structure and skin health. DermaClae has a couple unique properties that make it specifically designed for the face:

Because of the finer texture, DermaClae is designed to go through a small cannula, the same way you have likely received facial fillers previously. So, the experience in the chair should feel familiar to anyone who has had HA filler previously, only you are getting a long lasting product that is from fat.

How the two compare

	AlloClae	DermaClae
Designed for	Body	Face and delicate areas
Composition	About 60% adipocyte cell membrane, 40% extracellular matrix	Higher ratio of extracellular matrix
Texture	Structurally strong, holds projection	Much finer, smoother
Best at	Hip dips, buttock, lipo contour deformities	Targeted facial volume, natural softness
Delivery	Off the shelf	Off the shelf
Anesthesia	Local, in office	Local, in office
Donor site needed	None	None
Status	Available now	Expected later in 2026

Neither product is better than the other. They are good at different jobs. You pick based on what the area needs: structural strength or delicate artistic work.

Why “no donor site” is so important for our busy business professionals.

Here is what I run into every week: a patient loves the idea of fat. Natural, their own tissue, nothing synthetic. And then we start talking about liposuction, downtime, a second treated area, and the conversation changes.

Then there is the group that has been losing weight on a GLP-1 medication. They have made an incredible transformation for their health; however, they have minimal fat left to liposuction. Many of them simply do not have fat to harvest anymore, and the ones who do are not eager to touch it. For years, these patients didn’t have a lot of options. That has changed with DermaClae and AlloClae. They have given both plastic surgeons and patients options they have never had previously: a natural regenerative option that does not require downtime or liposuction.

Both of these products change the entire conversation. No liposuction. No second site to recover from where fat was liposuctioned. An office procedure under local anesthesia with immediate recovery and minimal to no downtime. For the busy professionals I treat, time is the most valuable thing they have, and this respects it.

Can you do the face and body at the same time?

Yes, and I think that is where this gets interesting. Something for the buttock, something for the breast, something for the face, in one visit, off the shelf, under local. A meaningful total transformation without an operating room or downtime.

Five years ago, that would not have been possible.

When is DermaClae available?

Early access to DermaClae is set for late 2026. Dr. Johnny Franco at Austin Plastic Surgeon is on the DermaClae advisory board, so we will keep everyone updated as soon as it is available in our office.

We are opening a waitlist later this year for patients who want to be in line when it arrives. If you have been holding off on facial filler because you wanted something more natural, that is the list to be on.

FAQ

By Dr. Johnny Franco

Austin Plastic Surgeon