Letybo

Consultations offered at our three convenient locations in Austin, TX, San Antonio, TX and Westlake Hills, TX

Written by Dr. Johnny Franco · Updated Plastic Surgeon · Diplomate, American Board of Plastic Surgery

Letybo is an FDA-approved prescription injectable that temporarily relaxes the muscles between your brows to smooth moderate-to-severe frown lines. You can see rejuvenated, natural appearing results in just a few days, with no downtime.

As Texas’s leading aesthetic destination, our team at Austin Plastic Surgeon can help you decide whether Letybo is right for you. Whether you want to address signs of aging, improve your body contours, or refine your facial features, our expert surgeons and staff provide compassionate, high-quality care to help you look radiant and feel like your best self.

To learn more about Letybo and schedule a consultation at one of our Texas locations, please contact us online or call today:

About Letybo

Developed by Hugel and FDA-approved on February 29, 2024, Letybo gently relaxes underlying muscles to smooth out wrinkles and fine lines that can make you look tired, stressed or aged. Letybo can also be used to create a subtle browlift. This helps open the eyes to give a refreshed and rejuvenated appearance to the face. It is a botulinum toxin type A injectable that works similarly to Botox and Dysport, using the same active ingredient to soften wrinkles. It acts as a temporary shield, blocking the nerve signals that instruct your muscles to contract. This lets the muscles on your forehead and between the eyes relax, leaving your skin youthful and smooth. (1)

The BLESS Phase 3 clinical trials demonstrated Letybo’s efficacy and safety. In one trial, nearly 65% of patients had their frown lines smoothed to clear or almost clear within one month, compared to 0% in the placebo group. Clinical data also confirmed high rates of patient satisfaction with no reported instances of drug resistance, allowing you to choose Letybo with complete confidence and peace of mind. (2)

Letybo vs. Botox and Other Neurotoxins

Although these botulinum toxin type A injectables serve similar purposes, each differs in its manufacturer, unique formulation, duration of results, and FDA-approved treatment areas. Understanding these subtle differences in formulation and performance can help determine which product aligns best with your aesthetic goals:

  • Letybo: A modern, highly purified formulation approved specifically for frown lines between the eyebrows, delivering predictable, targeted results. At our practice we also use Letybo around the mouth to improve fine lines or in the massetter to help shape and sculpt the face.
  • Botox: FDA-approved for the largest variety of cosmetic and medical concerns, including frown lines, forehead lines, crow’s feet, chronic migraines, and severe sweating.
  • Xeomin: Known as a “naked” formula with no extra proteins, meaning you are less likely to develop tolerance over years of continuous treatments. Great option for long-term users.
  • Daxxify: The longest-lasting treatment option, using a special peptide stabilizer instead of blood products so it sticks tightly to your nerves. Approved for frown lines, results can last six to nine months compared with three to four months for other treatments. Many patients also see a “Daxy” glow from its use and this is often attributed to the peptide associated with Daxxify.
  • Jeuveau: Made by Evolus and approved strictly for cosmetic frown lines. Is one of the few neuro-modulators designed specifically for aesthetic patients.

Because every individual reacts differently to neurotoxins, there is no single “best” option. Our team works closely with you to select the appropriate formula based on your personal aesthetic goals, budget, and treatment history.

Benefits

By choosing Letybo at Austin Plastic Surgeon, patients can experience numerous benefits, including: (2)

  • Reduces Wrinkles: Effectively smooths moderate-to-severe dynamic wrinkles and glabellar lines (wrinkles between the eyebrows) for a more youthful, rejuvenated appearance.
  • Natural-Looking Results: Targets specific muscles to preserve your natural range of facial expressions while avoiding an overfilled or artificial appearance
  • Fast Onset: Visible softening of dynamic wrinkles begins within just two to three days of treatment, offering a slightly faster response than traditional Botox.
  • Quick and Convenient Treatment: The procedure takes only 15 to 30 minutes and requires virtually no recovery time, letting patients resume daily activities right away.
  • Purified Formulation: This formula contains fewer proteins and additives, which may help reduce the risk of developing treatment resistance over time.

Candidates

You may be an ideal candidate for Letybo if you:

  • Wish to smooth moderate-to-severe vertical wrinkles between your eyebrows.
  • Are looking for a convenient, non-surgical treatment with quick recovery time and manageable maintenance.
  • Want a treatment that preserves your facial expressions while delivering rejuvenated, natural-looking results.
  • Are a long-time neurotoxin user who finds their current brand is becoming less effective due to treatment resistance.
  • Are in good overall health, with no active skin conditions, and maintain realistic expectations for treatment results.

Personal Consultation

Before your Letybo treatment, you will attend a personal consultation with us so we can understand your aesthetic goals and determine how best to serve you. During your appointment, you will meet with one of our expert specialists to discuss your overall health and lifestyle habits. They will perform a physical examination of your face, evaluating your skin health, baseline expressions, and dynamic muscles to determine whether Letybo best suits your features. Our team will evaluate your needs and facial features to help restore and enhance your features. A deep knowledge of the underlying anatomy allows our providers to statistically place Letybo to accentuate your features while giving you a natural, but rejuvenated appearance. Based on this assessment and your desired goals, your specialist will develop a tailored treatment plan for your specific needs. In addition to designing your customized approach, we will provide preparation and recovery instructions and a complete outline of treatment costs.

To schedule your personal consultation, please contact us online or call the office nearest to you:

Preparation

To achieve optimal results, each patient will receive comprehensive preparation instructions during their initial consultation. Our team will assist you throughout every step of the process. On the day of your procedure, please arrive with a clean face completely free of skincare products and makeup. There is minimal preparation which makes it attractive to so many of our patients. We do encourage our patients to have their treatment at least two weeks prior to any important event so that you can have the full effect of Letybo prior to your special event.

Procedure

Letybo treatment is performed in-office and is relatively quick, taking approximately 15 to 30 minutes. One of our expert specialists will begin by cleansing the skin and mapping the exact injection sites. When appropriate, they will apply a topical numbing cream to ensure the patient is comfortable. Using precise techniques, your specialist will then inject precise doses of Letybo into targeted areas and, if necessary, gently massage the area to help the formula integrate seamlessly into the tissue.

Recovery and Results

After your Letybo treatment, recovery is typically limited, and you may return to your normal activities the same day, although individual experiences can vary. While there is virtually no required downtime, mild redness, swelling, and tenderness at the injection sites are common directly after treatment but will usually fade within a few hours. For the first 4 hours, patients should refrain from rubbing, massaging, or touching the treated areas. (1)

Initial improvements are often noticeable within two to three days following treatment, with complete results appearing by two weeks. (2) Depending on your body’s natural metabolism and the degree of treatment, Letybo results can last up to three to four months. (1) To help preserve your smooth, youthful appearance and maintain your natural-looking results over time, your specialist may suggest ongoing follow-up treatments for longer-term aesthetic maintenance.

Corresponding Procedures

While Letybo relaxes muscles and smooths frown lines, it does not add volume or tighten the skin. You can pair Letybo with additional cosmetic treatments for more comprehensive facial rejuvenation. Additional treatments may include:

  • RF Microneedling: Tightens and firms skin texture and fine lines post-filler.
  • Sofwave: Ultrasound skin tightening for an overall upper-face refresh. It helps restore firmness and smooth the skin by stimulating collagen production.
  • Dermal Fillers: Softens deeper facial lines and restores volume and fullness to targeted areas in the face
  • Brow Lift: A surgical procedure for patients seeking longer-lasting results. Elevates drooping eyebrows and smooths forehead lines, addressing the root cause of upper eyelid hooding when brow descent contributes to excess skin.
  • AVAVA Laser: Skin resurfacing will work synergistically to improve the overall appearance of the skin. The AVAVA laser will improve the skin texture and help improve the tone of the skin.

Cost of Letybo in Austin, Texas

The cost of Letybo treatments depends on several factors, including the type of approach chosen, how often you need it, and other cost variables. After establishing your care plan during your consultation, we will provide a comprehensive price estimate. We also recommend checking out our perks memberships for exciting deals and specials.

To discover the total cost of your treatment, please contact us online or call us at one of our offices:

FAQ

What areas can Letybo treat?

Letybo is FDA-approved to treat moderate-to-severe glabellar lines, the vertical wrinkles that form between the eyebrows. By temporarily relaxing the underlying muscles responsible for these wrinkles, Letybo injectable can make the brow area look significantly smoother and more refreshed while still preserving a natural look.

How long will Letybo last?

Letybo results typically last three to four months. However, individual duration can vary based on personal factors such as your metabolism, facial muscle strength, dosage, and lifestyle habits. For instance, routine high-intensity exercise or frequent sun exposure may cause the effects to diminish more quickly. To help preserve your rejuvenated appearance, you should follow your specialist’s post-treatment guidelines carefully and support long-term skin health with proper sun protection and targeted topical care. (1)

Is Letybo Safe?

Letybo is an FDA-approved, highly purified botulinum toxin type A designed to soften moderate-to-severe frown lines. Backed by extensive clinical research, it offers a safe and reliable option for most adults when administered by an experienced medical professional, such as a specialist on our team. However, like all injectable treatments, Letybo carries potential side effects and risks. Your specialist will discuss these details with you during your consultation. (1)

References

  1. Masood M, Khan RSS, Masood S, Minhas UEA, Sohail S. Efficacy and Safety of LetibotulinumtoxinA for the Treatment of Moderate-to-Severe Glabellar Lines: A Systematic Review and Meta-Analysis of RCTs. Aesthetic plastic surgery. 2026;50(May 2026):10.1007/s00266-025-05550-z. doi:10.1007/s00266-025-05550-z
  2. Mueller DS, Prinz V, Adelglass J, et al. Efficacy and Safety of Letibotulinumtoxin in the Treatment of Glabellar Lines: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Phase 3 Study. Aesthet Surg J. 2022;42(6):677-688. doi:10.1093/asj/sjac019

About Dr. Johnny Franco

Plastic Surgeon · Austin Plastic Surgeon

Board certification
American Board of Plastic Surgery (verify)
Education and training
  • Bachelor of Science in Biochemistry, Beloit College
  • Doctorate of Medicine, University of Texas Medical Branch at Galveston
  • Residency, Plastic Surgery, Saint Louis University School of Medicine (chief resident 2010-2011)
  • Training, Microsurgery (cancer reconstruction), Chan Gung Hospital in Taiwan (2011)
  • Fellowship, Breast Reconstruction and Fat Transfer, Gent University Hospital in Belgium
Memberships
  • American Society of Plastic Surgeons
  • American Society for Aesthetic Plastic Surgery
  • Austin Society of Plastic and Reconstructive Surgeons
Awards
  • Merck Index Award
  • Walter S. Haven Prize
NPI
1053503672
Offices
Austin · San Antonio · West Lake Hills

Read Dr. Johnny Franco's full bio